Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

@inproceedings{Kugel2017CrypticIH,
  title={Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification},
  author={Susann Kugel and Martin Baunach and Philipp A. Baer and Mie Ishida-Ito and Srividhya Sundaram and Zhongli Xu and Michael Groll and Christian Hertweck},
  booktitle={Nature communications},
  year={2017}
}
Terpenoid natural products comprise a wide range of molecular architectures that typically result from C-C bond formations catalysed by classical type I/II terpene cyclases. However, the molecular diversity of biologically active terpenoids is substantially increased by fully unrelated, non-canonical terpenoid cyclases. Their evolutionary origin has remained enigmatic. Here we report the in vitro reconstitution of an unusual flavin-dependent bacterial indoloterpenoid cyclase, XiaF, together… CONTINUE READING
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