Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials.

@article{Mortimer2014CrypticEO,
  title={Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials.},
  author={Gysell M Mortimer and Neville J. Butcher and Anthony W Musumeci and Z. John Deng and Darren J. Martin and Rodney F. Minchin},
  journal={ACS nano},
  year={2014},
  volume={8 4},
  pages={3357-66}
}
While plasma proteins can influence the physicochemical properties of nanoparticles, the adsorption of protein to the surface of nanomaterials can also alter the structure and function of the protein. Here, we show that plasma proteins form a hard corona around synthetic layered silicate nanoparticles (LSN) and that one of the principle proteins is serum albumin. The protein corona was required for recognition of the nanoparticles by scavenger receptors, a major receptor family associated with… CONTINUE READING
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