Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

@article{Vaillancourt2005CrypticCB,
  title={Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis},
  author={Fr{\'e}d{\'e}ric H. Vaillancourt and Ellen Yeh and David A. Vosburg and Sarah E O'Connor and Christopher T Walsh},
  journal={Nature},
  year={2005},
  volume={436},
  pages={1191-1194}
}
Enzymatic incorporation of chlorine, bromine or iodine atoms occurs during the biosynthesis of more than 4,000 natural products. Halogenation can have significant consequences for the bioactivity of these products so there is great interest in understanding the biological catalysts that perform these reactions. Enzymes that halogenate unactivated aliphatic groups have not previously been characterized. Here we report the activity of five proteins—CmaA, CmaB, CmaC, CmaD and CmaE—in the… CONTINUE READING