Cryptic Pol II Transcripts Are Degraded by a Nuclear Quality Control Pathway Involving a New Poly(A) Polymerase

@article{Wyers2005CrypticPI,
  title={Cryptic Pol II Transcripts Are Degraded by a Nuclear Quality Control Pathway Involving a New Poly(A) Polymerase},
  author={Françoise Wyers and Mathieu Rougemaille and Gwena{\"e}l Badis and James Rousselle and M-A. Dufour and Jocelyne Boulay and B{\'e}atrice Regnault and Fr{\'e}d{\'e}ric Devaux and Abdelkader Namane and Bertrand S{\'e}raphin and Domenico Libri and Alain Jacquier},
  journal={Cell},
  year={2005},
  volume={121},
  pages={725-737}
}
Since detection of an RNA molecule is the major criterion to define transcriptional activity, the fraction of the genome that is expressed is generally considered to parallel the complexity of the transcriptome. We show here that several supposedly silent intergenic regions in the genome of S. cerevisiae are actually transcribed by RNA polymerase II, suggesting that the expressed fraction of the genome is higher than anticipated. Surprisingly, however, RNAs originating from these regions are… CONTINUE READING
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