Crypt stem cells as the cells-of-origin of intestinal cancer

@article{Barker2009CryptSC,
  title={Crypt stem cells as the cells-of-origin of intestinal cancer},
  author={N. Barker and R. Ridgway and J. V. Es and M. Wetering and H. Begthel and M. V. D. Born and Esther Danenberg and A. Clarke and O. Sansom and H. Clevers},
  journal={Nature},
  year={2009},
  volume={457},
  pages={608-611}
}
Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a previously established Lgr5 (leucine-rich-repeat containing G-protein-coupled receptor 5) knockin mouse model, a tamoxifen-inducible Cre recombinase is expressed in long-lived intestinal stem cells. Here we show that deletion of Apc in these stem cells leads to their transformation within days. Transformed stem… Expand
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