Crypt/villus site of substrate-dependent regulation of mouse intestinal glucose transporters.

@article{Ferraris1993CryptvillusSO,
  title={Crypt/villus site of substrate-dependent regulation of mouse intestinal glucose transporters.},
  author={Ronaldo P. Ferraris and Jared M. Diamond},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 12},
  pages={
          5868-72
        }
}
The intestinal epithelium is in a constant state of turnover, with cells differentiating at the crypts and then migrating toward the tips of the villi. Does substrate-dependent regulation of intestinal Na+/D-glucose cotransporters occur only in crypt cells, or can transport activity be subsequently reprogrammed in mature enterocytes? We used in situ, glucose-protectable specific phlorizin binding to determine site density of brush border glucose transporters in enterocytes fractionated along… CONTINUE READING

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