Cryoprotectants for freeze drying of drug nano-suspensions: effect of freezing rate.

@article{Lee2009CryoprotectantsFF,
  title={Cryoprotectants for freeze drying of drug nano-suspensions: effect of freezing rate.},
  author={Min Kyung Lee and Min Young Kim and Sujung Kim and Jonghwi Lee},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 12},
  pages={4808-17}
}
Drug nanoparticles are often prepared in a liquid medium, and a drying method such as freeze drying is used to convert them to an oral solid dosage form. When the dried form is reconstituted in an aqueous system, it may be redispersed to achieve its original particle size. The redispersibility of dried nanoparticles depends on the parameters of the freeze drying process. In this study, an apparatus with a freezing rate gradient was used to systematically investigate the effect of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Development and lyophilization of itraconazole loaded poly(butylcyanoacrylate) nanospheres as a drug delivery system.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Critical freezing rate in freeze drying nanocrystal dispersions.

Journal of controlled release : official journal of the Controlled Release Society • 2006
View 10 Excerpts

Freeze-drying of composite core-shell nanoparticles.

Drug development and industrial pharmacy • 2006

Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V • 2006
View 2 Excerpts

Unit operations of chemical engineering

WL McCabe, JC Smith, P. Harriott
Columbus, OH: McGraw- Hill. pp. 299–324. L OF PHARMACEUTICAL SCIENCES, • 2005
View 2 Excerpts

Similar Papers

Loading similar papers…