Cryoprotectants for freeze drying of drug nano-suspensions: effect of freezing rate.

  title={Cryoprotectants for freeze drying of drug nano-suspensions: effect of freezing rate.},
  author={Min Kyung Lee and Min Young Kim and Sujung Kim and Jonghwi Lee},
  journal={Journal of pharmaceutical sciences},
  volume={98 12},
Drug nanoparticles are often prepared in a liquid medium, and a drying method such as freeze drying is used to convert them to an oral solid dosage form. When the dried form is reconstituted in an aqueous system, it may be redispersed to achieve its original particle size. The redispersibility of dried nanoparticles depends on the parameters of the freeze drying process. In this study, an apparatus with a freezing rate gradient was used to systematically investigate the effect of… CONTINUE READING


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