Cryopreservation-induced nonattachment of human hepatocytes: role of adhesion molecules.

  title={Cryopreservation-induced nonattachment of human hepatocytes: role of adhesion molecules.},
  author={Claire Terry and R. D. Hughes and Ragai R. Mitry and Sharon C. Lehec and Anil Dhawan},
  journal={Cell transplantation},
  volume={16 6},
Good quality cryopreserved human hepatocytes are becoming an important source for clinical hepatocyte transplantation. However, the process of cryopreservation leads to both structural and functional impairment of hepatocytes. The aim of this study was to investigate the mechanisms of cryopreservation-induced nonattachment in human hepatocytes. Hepatocytes were cryopreserved after isolation from unused donor liver tissue. Cell attachment to collagen-coated plates was measured. A cDNA gene array… CONTINUE READING
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