Cryopreservation Prevents Arterial Allograft Dilation

  title={Cryopreservation Prevents Arterial Allograft Dilation 
  author={Joseph S. Giglia and Jeremy D. Ollerenshaw and Patti E. Dawson and Kirby S. Black and William M. Abbott},
  journal={Annals of Vascular Surgery},
Historically, immune-mediated degradation and subsequent aneurysm formation have limited the usefulness of cryopreserved arterial allografts. This study tested the hypothesis that modern cryopreserved arterial allografts are protected from immune-mediated dilation. Abdominal aortas were harvested from anesthetized rats (Lewis and Brown-Norway) for immediate implantation or cryopreservation. Subsequently, Lewis rats underwent infrarenal aortic replacement with either an acutely harvested or a… 

Long-term behaviour of cryopreserved arterial grafts versus prosthetic micrografts.

The influence of cryopreservation on changes in diameter and compliance of allografts in an animal experimental model.

Transplantation of Vascular Allograft

The iliolumbar vein to abdominal aortic transplantation model between syngeneic animals is useful to study vein graft intimal hyperplasia which represents a significant clinical problem in vascular medicine.

[The place of arterial allograft in reconstructive surgery of the main arteries of the lower extremities].

In this analysis, the directions of development of vascular allotransplantation, global trends related to indications for their use, methods of conservation, degradation and endothelial dysfunction are reflected and it is wrong to recommend using arterial allografts always.

Cardiovascular tissue engineering: state of the art Ingenierie tissulaire appliqué aux vaisseaux sanguins : état de l'art

In patients requiring coronary or peripheral vascular bypass procedures, autogenous arterial or vein grafts remain as the conduit of choice even in the case of redo patients, and both endothelialisation of grafts and the construction of biological cardiovascular conduits are reviewed.



Evaluation of Cryopreserved Arteries as Alternative Small Vessel Prostheses

Biologic or synthetic grafts have had limited success in small vessel applications. Studies were initiated to assess the potential use of cryopreserved (CP) arteries as coronary artery bypass

Failure of cryopreserved saphenous vein allografts following coronary artery bypass surgery.

The use of cryopreserved saphenous veins for coronary artery bypass should be severely restricted because of poor patency compared to autologous conduits.

Antigenicity of Venous Allografts

It is indicated that unmodified veins are normally antigenic and that this antigenicity is not eliminated by cryopreservation with or without DMSO, and that gluteraldehyde treatment appears to reduce allograft antigenicity, but results in a nonviable graft.

Smooth Muscle Function in Short- and Long-term Stored Cryopreserved Veins

It is demonstrated that vein viability is maintained in cryopreserved banked veins during long-term liquid nitrogen storage.

Early results of infrageniculate arterial reconstruction using cryopreserved homograft saphenous conduit (CADVEIN) and combination low-dose systemic immunosuppression.

The data suggest that Imsup significantly improves CADVEIN patency with limited systemic morbidity; however, complications related to the conduit itself occurred with greater frequency and cause greater morbidity than when the autogenous veins were used.

Femorodistal Bypass Using Cryopreserved Venous Allografts for Limb Salvage

Evaluating the usefulness of cryopreserved venous allografts (CPVA) as an arterial substitute in patients with severe distal arterial occlusive disease found doppler ultrasound surveillance of a subcutaneous graft allows accurate assessment and repair of the abnormalities with no increase in mortality or morbidity.