Cryopreservation Enables Long-Term Storage of 9-(2-Phosphonylmethoxy-ethyl) Adenine Prodrug-Loaded Reconstituted Lactosylated High-Density Lipoprotein

Abstract

Chronic hepatitis B is caused by an infection of parenchymal liver cells with hepatitis B virus (HBV). The nucleoside analog 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a promising candidate drug for the treatment of HBV infections. PMEA effectively inhibits the replication HBV in cell culture (1,2), and the orally available bis(POM) derivative has… (More)
DOI: 10.1023/A:1011079603123

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@article{Vrueh2001CryopreservationEL, title={Cryopreservation Enables Long-Term Storage of 9-(2-Phosphonylmethoxy-ethyl) Adenine Prodrug-Loaded Reconstituted Lactosylated High-Density Lipoprotein}, author={Remco L. A. de Vrueh and Theo J. C. van Berkel and Martin K. Bijsterbosch}, journal={Pharmaceutical Research}, year={2001}, volume={18}, pages={403-407} }