Cryopreparation of biological specimens for immunoelectron microscopy.

  title={Cryopreparation of biological specimens for immunoelectron microscopy.},
  author={Wiebke M{\"o}bius},
  journal={Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft},
  volume={191 3},
Cryopreparation methods for transmission electron microscopy comprise a variety of different low temperature approaches. For any particular specimen a careful comparison of preparation methods should be made with respect to the preservation of structure and antigenicity. Here an overview of cryomethods is provided especially suitable for immunoelectron microscopy. Replacing chemical fixation by cryofixation, which immobilizes a sample physically by rapid freezing, is the basis of several… CONTINUE READING


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Freeze-substitution for immunochemistry

  • B. M. Humbel, H. Schwarz
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  • 1989
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