• Corpus ID: 17263979

Cryolipolysis: a historical perspective and current clinical practice.

  title={Cryolipolysis: a historical perspective and current clinical practice.},
  author={Hrak Ray Jalian and Mathew M. Avram},
  journal={Seminars in cutaneous medicine and surgery},
  volume={32 1},
  • H. JalianM. Avram
  • Published 2013
  • Biology, Medicine
  • Seminars in cutaneous medicine and surgery
Dermatologists have long used cold-based therapeutic approaches for a variety of applications. Based on the differences in chemical composition, it is possible to selectively target certain tissues rich with lipid, while sparing the surrounding tissue predominantly containing water. With historical observations of cold-induced panniculitis suggesting the feasibility of this strategy, cryolipolysis has emerged as a new methodology using controlled cooling to selectively target fat. Both… 

Figures from this paper

Cryolipolysis: Clinical Best Practices and Other Nonclinical Considerations

Insights from 8 plastic surgeons with regard to cryolipolysis best practices from a clinical perspective and the impact of integrating this noninvasive body contouring procedure into a plastic surgery practice are reported.

Utilisation of Cryolipolysis among Asians: A Review on Efficacy and Safety

Cryolipolysis utilisation among Asians or darker skin types provides the same efficacy and safety profiles as in Caucasians, and might be proposed as the first treatment choice for Asian patients who opted to do body contouring.

Cryotherapy-induced lipolysis

Human and animal studies have revealed that cryolipolysis can significantly decrease subcutaneous fat and change body contour without causing damage to the overlying skin and surrounding structures or deleterious changes in blood lipids.

Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction

In clinical studies, cryolipolysis was shown to reduce subcutaneous fat at the treatment site by up to 25% after one treatment, and the patient satisfaction rate is higher than with other technologies used for noninvasive lipolysis.

Frostbite following cryolipolysis: a case report

A case of severe frostbite following a cryolipolysis session that required surgical intervention with resultant permanent scarring is reported.

Adverse Events Associated With Cryolipolysis: A Systematic Review of the Literature.

The most common AEs associated with cryolipolysis were treatment site erythema, numbness/paresthesia, bruising, and edema, and more serious complications include severe/persistent pain, dysesthesia, skin hyperpigmentation, motor neuropathy, and paradoxical adipose hyperplasia.

Cryolipolysis and Skin Tightening

A clinical evaluation of patients treated with cryolipolysis assesses changes to skin texture, laxity, and cellulite at 2 study centers and finds consistent improvement in skin texture and laxity for treatments to the outer thighs, abdomen, arms, and back.

Cryolipolysis (CLL) for Reduction of Localized Subcutaneous Fat: Review of the Literature and an Evidence-Based Analysis

Most reports about CLL included in this review lacked rigorous scientific methodology in study design or in outcome measurement, and further research should be encouraged to prove with methodological rigor positive effects of this treatment modality.

Multiple same day cryolipolysis treatments for the reduction of subcutaneous fat are safe and do not affect serum lipid levels or liver function tests

Whether multiple same day treatments (abdomen plus both flanks) result in changes in serum lipid levels or liver tests, and is safe, is determined.

The efficacy of cryolipolysis treatment on arms and inner thighs

The new cryolipolysis flat cup vacuum applicator provided beneficial effects for circumferential reduction of arms and inner thighs.



Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves

Noninvasive cryolipolysis results in substantial fat reduction within 2 months of treatment without damage to skin, and the procedure is associated with modest reversible short-term changes in the function of peripheral sensory nerves.

Cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results from a Pig Model

Cryolipolysis is worthy of further study because it has been shown to significantly decrease subcutaneous fat and change body contour without causing damage to the overlying skin and surrounding structures or deleterious changes in blood lipids.

History of cryosurgery.

  • A. Gage
  • Medicine
    Seminars in surgical oncology
  • 1998
The use of freezing temperatures for the therapeutic destruction of tissue began in England in 1845-51 when James Arnott described the use of iced salt solutions (about-20 degrees C) to freeze

Selective cryolysis: A novel method of non‐invasive fat removal

This study describes non‐invasive cold‐induced selective destruction of subcutaneous fat in mice through cryosurgery at very low temperatures.

Non‐invasive cryolipolysis for body contouring in Chinese—a first commercial experience

The objective of the study is to determine the clinical efficacy and patient satisfaction of a novel cryolipolysis device (Zeltiq®) for body contouring in Chinese after a single treatment and after 2


A description will be given of a peculiar morbid condition, of which Hochsinger describes the lesion he observed as an acute freezing reaction, occurring in very young children, and presenting a firm thickeniug of the subcutaneous tissue below tbe chin.

Cold panniculitis in children.

Five additional cases of hardening of tissue in the submental region in children, related to cold exposure, are described, four in children aged 6 months to 3 years, and one in a 17-year-old girl.

Non‐invasive cryolipolysis™ for subcutaneous fat reduction does not affect serum lipid levels or liver function tests

This study was intended to more fully document any effect of this procedure on lipid and liver‐related blood tests.

Cold panniculitis in children. Adiponecrosis E frigore of Haxthausen.

Two cases of pannicultis which developed in apparently healthy Negro infants after exposure to cold are described.