Cryofibrinogenemia-Induced Cutaneous Ulcers: A Review and Diagnostic Criteria

  title={Cryofibrinogenemia-Induced Cutaneous Ulcers: A Review and Diagnostic Criteria},
  author={Ayman Grada and Vincent Falanga},
  journal={American Journal of Clinical Dermatology},
  • A. Grada, V. Falanga
  • Published 1 February 2017
  • Medicine
  • American Journal of Clinical Dermatology
Chronic skin ulcers are frequently encountered in clinical practice and are often due to very heterogeneous etiologies. Cryofibrinogenemia is an unusual cause of non-healing skin ulcers. It is a small-vessel occlusive vascular disorder that results from the precipitation of cryofibrinogens in plasma. The lack of definitive diagnostic criteria means cryofibrinogenemia remains an under-diagnosed entity that causes significant morbidity. One of the most common manifestations of cryofibrinogenemia… 
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Healing of Ulcers due to Cryofibrinogenemia with Colchicine and High-Dose Pentoxifylline
This is the first report documenting use of the combination of colchicine and high-dose pentoxifylline to successfully treat ulcers due to cryofibrinogenemia, a 61-year-old male smoker with a 10-year history of intermittent ulcerations.
Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia.
Stanozolol is a safe and effective treatment of the cutaneous manifestations of cryofibrinogenemia, and has minimal side effects.
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In patients with spontaneous ulceration of the extremities, particularly when they do not respond appropriately to standard therapy, the possibility of cryoglobulinemia or cryofibrinogenemia should be considered.
Prevalence and clinical significance of cryofibrinogenaemia in patients with renal disorders.
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  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2011
Cryofibrinogenaemia is detected in up to 11% of patients with renal disorders, and in such patients, the presence of CryoFg is associated with thrombotic events.
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