Cryofibrinogenemia-Induced Cutaneous Ulcers: A Review and Diagnostic Criteria

@article{Grada2016CryofibrinogenemiaInducedCU,
  title={Cryofibrinogenemia-Induced Cutaneous Ulcers: A Review and Diagnostic Criteria},
  author={Ayman Grada and Vincent Falanga},
  journal={American Journal of Clinical Dermatology},
  year={2016},
  volume={18},
  pages={97-104}
}
  • A. Grada, V. Falanga
  • Published 1 February 2017
  • Medicine
  • American Journal of Clinical Dermatology
Chronic skin ulcers are frequently encountered in clinical practice and are often due to very heterogeneous etiologies. Cryofibrinogenemia is an unusual cause of non-healing skin ulcers. It is a small-vessel occlusive vascular disorder that results from the precipitation of cryofibrinogens in plasma. The lack of definitive diagnostic criteria means cryofibrinogenemia remains an under-diagnosed entity that causes significant morbidity. One of the most common manifestations of cryofibrinogenemia… 
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