Cryoelectron tomography of radial spokes in cilia and flagella

@inproceedings{Pigino2011CryoelectronTO,
  title={Cryoelectron tomography of radial spokes in cilia and flagella},
  author={Gaia Pigino and Khanh Huy Bui and Aditi Maheshwari and Pietro Lupetti and Dennis R. Diener and Takashi Ishikawa},
  booktitle={The Journal of cell biology},
  year={2011}
}
Radial spokes (RSs) are ubiquitous components in the 9 + 2 axoneme thought to be mechanochemical transducers involved in local control of dynein-driven microtubule sliding. They are composed of >23 polypeptides, whose interactions and placement must be deciphered to understand RS function. In this paper, we show the detailed three-dimensional (3D) structure of RS in situ in Chlamydomonas reinhardtii flagella and Tetrahymena thermophila cilia that we obtained using cryoelectron tomography (cryo… CONTINUE READING
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