Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication.

@article{Jiang2006CryoelectronMS,
  title={Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication.},
  author={Xiaofang Jiang and Hariharan Jayaram and Mukesh Kumar and Steven J. Ludtke and Mary K. Estes and B. V. Venkataram Prasad},
  journal={Journal of virology},
  year={2006},
  volume={80 21},
  pages={
          10829-35
        }
}
The replication and packaging of the rotavirus genome, comprising 11 segments of double-stranded RNA, take place in specialized compartments called viroplasms, which are formed during infection and involve a coordinated interplay of multiple components. Two rotavirus nonstructural proteins, NSP2 (with nucleoside triphosphatase, single-stranded RNA [ssRNA] binding and helix-destabilizing activities) and NSP5, are essential in these events. Previous structural analysis of NSP2 showed that it is… CONTINUE READING

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Structure-function analysis of rotavirus NSP2 octamer by using a novel complementation system

  • Z. F. Taraporewala, X. Jiang, R. Vasquez-Del Carpio, H. Jayaram, B. V. Prasad, J. T. Patton
  • J. Virol
  • 2006
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