Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.

@article{Mikyas2004CryoelectronMI,
  title={Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.},
  author={Yeshi Mikyas and Miriam Makabi and Sujna Raval-Fernandes and Laura H. Harrington and Valerie A. Kickhoefer and Leonard H Rome and Phoebe L. Stewart},
  journal={Journal of molecular biology},
  year={2004},
  volume={344 1},
  pages={
          91-105
        }
}
The vault is a highly conserved ribonucleoprotein particle found in all higher eukaryotes. It has a barrel-shaped structure and is composed of the major vault protein (MVP); vault poly(ADP-ribose) polymerase (VPARP); telomerase-associated protein 1 (TEP1); and small untranslated RNA (vRNA). Although its strong conservation and high abundance indicate an important cellular role, the function of the vault is unknown. In humans, vaults have been implicated in multidrug resistance during… CONTINUE READING
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