Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor.

@article{Sharma1998CryoelectronMA,
  title={Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor.},
  author={Manjuli Rani Sharma and Pawel Penczek and Robert A. Grassucci and Haipeng Xin and Siegfried Fleischer and Terence Wagenknecht},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 29},
  pages={
          18429-34
        }
}
The three-dimensional structure of the cardiac muscle ryanodine receptor (RyR2) is described and compared with its skeletal muscle isoform (RyR1). Previously, structural studies of RyR2 have not been as informative as those for RyR1 because optimal conditions for electron microscopy, which require low levels of phospholipid, are destabilizing for RyR2. A simple procedure was devised for diluting RyR2 (in phospholipid-containing buffer) into a lipid-free buffer directly on the electron… CONTINUE READING
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