Cryoablative response of prostate cancer cells is influenced by androgen receptor expression.

@article{Klossner2008CryoablativeRO,
  title={Cryoablative response of prostate cancer cells is influenced by androgen receptor expression.},
  author={Daniel P. Klossner and John M Baust and Robert G Vanbuskirk and Andrew A. Gage and John G. Baust},
  journal={BJU international},
  year={2008},
  volume={101 10},
  pages={1310-6}
}
OBJECTIVE To investigate in prostate cancer cells the consequences of androgen-insensitivity (AI) development on the cellular and molecular responses to freezing, as a challenge in prostate cancer treatment occurs when the androgen-sensitive (AS) phenotype switches to an AI phenotype, the latter of which is often refractory to many therapies. MATERIALS AND METHODS PC-3 (AI) and LNCaP (AS) were each genetically altered to express the opposite phenotype and subjected to an in vitro freezing… CONTINUE READING

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Cryosurgery – a putative

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