CryoEM structure of the tegumented capsid of Epstein-Barr virus

@article{Li2020CryoEMSO,
  title={CryoEM structure of the tegumented capsid of Epstein-Barr virus},
  author={Zhihai Li and Xiao Zhang and Lili Dong and Jin Keun Pang and Miao Xu and Qian Zhong and Mu-Sheng Zeng and Xuekui Yu},
  journal={Cell Research},
  year={2020},
  volume={30},
  pages={873 - 884}
}
Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ portal from the tegumented capsid adopts a closed conformation with its channel valve holding the terminal viral DNA and with its crown region firmly engaged by three layers of ring… Expand
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