CryoEM structure of the tegumented capsid of Epstein-Barr virus

  title={CryoEM structure of the tegumented capsid of Epstein-Barr virus},
  author={Zhihai Li and Xiao Zhang and Lili Dong and Jin Keun Pang and Miao Xu and Qian Zhong and Mu-Sheng Zeng and Xuekui Yu},
  journal={Cell Research},
  pages={873 - 884}
Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ portal from the tegumented capsid adopts a closed conformation with its channel valve holding the terminal viral DNA and with its crown region firmly engaged by three layers of ring… Expand
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  • Medicine
  • Nature communications
  • 2021
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The Epstein-Barr virus (EBV) infects more than 95% of adults worldwide and is associated with various malignant tumors and immune diseases, imparting a huge disease burden on the human population.Expand


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