Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

@article{Fica2017CryoelectronMS,
  title={Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine},
  author={Sebastian M Fica and Kiyoshi Nagai},
  journal={Nature Structural &Molecular Biology},
  year={2017},
  volume={24},
  pages={791-799}
}
The spliceosome excises introns from pre-messenger RNAs using an RNA-based active site that is cradled by a dynamic protein scaffold. A recent revolution in cryo-electron microscopy (cryo-EM) has led to near-atomic-resolution structures of key spliceosome complexes that provide insight into the mechanism of activation, splice site positioning, catalysis, protein rearrangements and ATPase-mediated dynamics of the active site. The cryo-EM structures rationalize decades of observations from… CONTINUE READING
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