Cryo-electron microscopy of viruses
@article{Adrian1984CryoelectronMO, title={Cryo-electron microscopy of viruses}, author={M. Adrian and J. Dubochet and J. Lepault and A. McDowall}, journal={Nature}, year={1984}, volume={308}, pages={32-36} }
Thin vitrified layers of unfixed, unstained and unsupported virus suspensions can be prepared for observation by cryo-electron microscopy in easily controlled conditions. The viral particles appear free from the kind of damage caused by dehydration, freezing or adsorption to a support that is encountered in preparing biological samples for conventional electron microscopy. Cryo-electron microscopy of vitrified specimens offers possibilities for high resolution observations that compare… CONTINUE READING
Topics from this paper
Paper Mentions
News Article
News Article
1,026 Citations
Study of vitrified, unstained frozen tissue sections by cryoimmunoelectron microscopy.
- Biology, Medicine
- Journal of cell science
- 1991
- 32
- PDF
Cryo-electron microscopy of vitrified specimens.
- Materials Science, Medicine
- Quarterly reviews of biophysics
- 1988
- 1,842
- PDF
Cryo-electron microscopy of vitrified insect flight muscle.
- Materials Science, Medicine
- Journal of molecular biology
- 1984
- 52
Observation of Bacteriophage Ultrastructure by Cryo-electron Microscopy.
- Materials Science, Medicine
- Methods in molecular biology
- 2018
- 2
Contrast of biological cryosections in scanning transmission electron microscopy
- Materials Science
- 1985
- 5
Cryogenic transmission electron microscopy: aqueous suspensions of nanoscale objects.
- Materials Science, Medicine
- Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
- 2013
- 32
Realizing the potential of electron cryo-microscopy.
- Materials Science, Medicine
- Quarterly reviews of biophysics
- 2004
- 197
References
SHOWING 1-10 OF 28 REFERENCES
Electron microscopy of frozen hydrated sections of vitreous ice and vitrified biological samples
- Materials Science, Medicine
- Journal of microscopy
- 1983
- 221
Electron microscopy of frozen biological suspensions
- Materials Science, Medicine
- Journal of microscopy
- 1983
- 200
- PDF
Freezing, sectioning and observation artefacts of frozen hydrated sections for electron microscopy
- Chemistry
- 1983
- 67
Projected structure of unstained, frozen‐hydrated T‐layer of Bacillus brevis.
- Biology, Medicine
- The EMBO journal
- 1984
- 61
The size of the bacteriophage T4 head in solution with comments about the dimension of virus particles as visualized by electron microscopy.
- Chemistry, Medicine
- Journal of molecular biology
- 1978
- 26
Beef liver catalase structure: interpretation of electron micrographs.
- Chemistry, Medicine
- Journal of molecular biology
- 1975
- 106
Capsid geometry of bacteriophage T2: a freeze-etching study.
- Materials Science, Medicine
- Journal of molecular biology
- 1975
- 54