Cryo-electron microscopy of viruses

@article{Adrian1984CryoelectronMO,
  title={Cryo-electron microscopy of viruses},
  author={Marc Adrian and Jacques Dubochet and Jean Lepault and Alasdair W. McDowall},
  journal={Nature},
  year={1984},
  volume={308},
  pages={32-36}
}
Thin vitrified layers of unfixed, unstained and unsupported virus suspensions can be prepared for observation by cryo-electron microscopy in easily controlled conditions. The viral particles appear free from the kind of damage caused by dehydration, freezing or adsorption to a support that is encountered in preparing biological samples for conventional electron microscopy. Cryo-electron microscopy of vitrified specimens offers possibilities for high resolution observations that compare… 

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