Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles.

  title={Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles.},
  author={Xuekui Yu and Ming Zhe Qiao and Ivo Atanasov and Zongyi Hu and Takanobu Kato and Tehming Liang and Z. Hong Zhou},
  volume={367 1},
The structural details of hepatitis C virus (HCV) have been elusive because of the lack of a robust tissue culture system for producing an adequate amount of virions from infectious sources for in-depth three-dimensional (3D) structural analysis. Using both negative-stain and cryo-electron microscopy (cryoEM), we show that HCV virions isolated from cell culture have a rather uniform size of 500 A in diameter and that recombinantly expressed HCV-like particles (HCV-LPs) have similar morphologic… CONTINUE READING


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