Cryo-EM structures of Tau filaments from Alzheimer’s disease brain

@inproceedings{Fitzpatrick2017CryoEMSO,
  title={Cryo-EM structures of Tau filaments from Alzheimer’s disease brain},
  author={Anthony W. Fitzpatrick and Benjamin Falcon and Shaoda He and Alexey G. Murzin and Garib N Murshudov and Holly J. Garringer and R. A. Crowther and Bernardino Ghetti and Michel Goedert and Sjors H. W. Scheres},
  booktitle={Nature},
  year={2017}
}
Alzheimer’s disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau filaments with different morphologies characterize other neurodegenerative diseases. No high-resolution structures of tau filaments are available. Here we present cryo-electron… CONTINUE READING

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