Cryo-EM structure of substrate-bound human telomerase holoenzyme

  title={Cryo-EM structure of substrate-bound human telomerase holoenzyme},
  author={Thi Hoang Duong Nguyen and Jane Tam and Robert Alexander Wu and Basil Greber and Daniel B. Toso and Eva Nogales and Kathleen Collins},
The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of telomeres during genome replication. Telomerase regulation has been implicated in cancer, other human diseases, and ageing, but progress towards clinical manipulation of telomerase has been hampered by the lack of structural data. Here we present the cryo-electron microscopy structure of the substrate-bound human telomerase holoenzyme at subnanometre resolution, showing two flexibly RNA-tethered lobes: the… CONTINUE READING