Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution

@article{Ecken2016CryoEMSO,
  title={Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution},
  author={Julian von der Ecken and Sarah M. Heissler and Salma Pathan-Chhatbar and Dietmar J Manstein and Stefan Raunser},
  journal={Nature},
  year={2016},
  volume={534},
  pages={724-728}
}
The interaction of myosin with actin filaments is the central feature of muscle contraction and cargo movement along actin filaments of the cytoskeleton. The energy for these movements is generated during a complex mechanochemical reaction cycle. Crystal structures of myosin in different states have provided important structural insights into the myosin motor cycle when myosin is detached from F-actin. The difficulty of obtaining diffracting crystals, however, has prevented structure… CONTINUE READING
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