Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

@inproceedings{Karuppasamy2017CryoEMSO,
  title={Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2},
  author={Manikandan Karuppasamy and Beata Kusmider and Taiana M Oliveira and Christl Gaubitz and Manoel Prouteau and Robbie Loewith and Christiane Schaffitzel},
  booktitle={Nature Communications},
  year={2017}
}
The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes, conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamycin. Here, we present the structure of Saccharomyces cerevisiae TORC2 determined by electron cryo-microscopy. TORC2 contains six subunits assembling into a 1.4 MDa rhombohedron. Tor2 and Lst8 form the common core of both TOR complexes. Avo3/Rictor is unique to TORC2, but… CONTINUE READING
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