Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.

@article{Elmlund2009CryoEMRP,
  title={Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.},
  author={Hans Elmlund and Vera Baraznenok and Tomas Linder and Zsolt Szil{\'a}gyi and Reza Rofougaran and Anders Hofer and Hans Hebert and Martin L. Lindahl and Claes M Gustafsson},
  journal={Structure},
  year={2009},
  volume={17 11},
  pages={
          1442-52
        }
}
The general transcription factor IID (TFIID) is required for initiation of RNA polymerase II-dependent transcription at many eukaryotic promoters. TFIID comprises the TATA-binding protein (TBP) and several conserved TBP-associated factors (TAFs). Recognition of the core promoter by TFIID assists assembly of the preinitiation complex. Using cryo-electron microscopy in combination with methods for ab initio single-particle reconstruction and heterogeneity analysis, we have produced density maps… CONTINUE READING
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