Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase.

Abstract

The DNA-dependent protein kinase (DNA-PK) plays an important role in mammalian DNA double-strand break repair and immunoglobulin gene rearrangement. The DNA-PK holoenzyme is activated by assembly at DNA ends and is comprised of DNA-PKcs, a 460 kDa protein kinase catalytic subunit, and Ku, a 70 kDa/80 kDa heterodimeric DNA-targeting component. We have solved… (More)

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Cite this paper

@article{Chiu1998CryoEMIO, title={Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase.}, author={C. Y. Chiu and Robert B. Cary and D. J. Chen and Scott Peterson and Phoebe L. Stewart}, journal={Journal of molecular biology}, year={1998}, volume={284 4}, pages={1075-81} }