Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice.

@article{Schnapp2002CruzipainIB,
  title={Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice.},
  author={Anita R Schnapp and Chris S Eickhoff and Donata Sizemore and Roy Curtiss and Daniel F. Hoft},
  journal={Infection and immunity},
  year={2002},
  volume={70 9},
  pages={
          5065-74
        }
}
Cruzipain, the major cysteinyl proteinase of Trypanosoma cruzi, is expressed by all developmental forms and strains of the parasite and stimulates potent humoral and cellular immune responses during infection in both humans and mice. This information suggested that cruzipain could be used to develop an effective T. cruzi vaccine. To study whether cruzipain-specific T cells could inhibit T. cruzi intracellular replication, we generated cruzipain-reactive CD4(+) Th1 cell lines. These T cells… CONTINUE READING

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