Crumbs3 is essential for proper epithelial development and viability.

  title={Crumbs3 is essential for proper epithelial development and viability.},
  author={Eileen L. Whiteman and Shuling Fan and Jennifer L. Harder and Katherine D. Walton and Chia-Jen Liu and Abdul Soofi and Vanessa C. Fogg and Marc B Hershenson and Gregory R Dressler and Gail Deutsch and Deborah L Gumucio and Ben L Margolis},
  journal={Molecular and cellular biology},
  volume={34 1},
First identified in Drosophila, the Crumbs (Crb) proteins are important in epithelial polarity, apical membrane formation, and tight junction (TJ) assembly. The conserved Crb intracellular region includes a FERM (band 4.1/ezrin/radixin/moesin) binding domain (FBD) whose mammalian binding partners are not well understood and a PDZ binding motif that interacts with mammalian Pals1 (protein associated with lin seven) (also known as MPP5). Pals1 binds Patj (Pals1-associated tight-junction protein… CONTINUE READING
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