Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2/M arrest and hyperacetylation of Histone H3.

@article{OliverasFerraros2011CrudePE,
  title={Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2/M arrest and hyperacetylation of Histone H3.},
  author={Cristina Oliveras-Ferraros and Salvador Fern{\'a}ndez-Arroyo and Alejandro V{\'a}zquez-Mart{\'i}n and Jes{\'u}s Lozano-S{\'a}nchez and S{\'i}lvia Cuf{\'i} and Jorge Joven and Vicente Micol and Alberto Fernandez-Guti{\'e}rrez and Antonio Segura-Carretero and Javier A. Men{\'e}ndez},
  journal={International journal of oncology},
  year={2011},
  volume={38 6},
  pages={1533-47}
}
Characterization of the molecular function of complex phenols naturally present in extra virgin olive oil (EVOO) against the HER2-gene amplified JIMT-1 cell line, a unique breast cancer model that inherently exhibits cross-resistance to multiple HER1/2-targeted drugs including trastuzumab, gefitinib, erlotinib and lapatinib, may underscore innovative cancer molecules with novel therapeutic targets because they should efficiently circumvent de novo resistance to HER1/2 inhibitors in order to… CONTINUE READING

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