Cruciferous Vegetables and Cancer Prevention

  title={Cruciferous Vegetables and Cancer Prevention},
  author={Genoveva Murillo and Rajendra G Mehta},
  journal={Nutrition and Cancer},
  pages={17 - 28}
In recent years, cancer prevention by natural products has received considerable attention. The potential protective role of cruciferous vegetables and active components present in these vegetables, such as isothiocyanates and indole-3-carbinol, has been extensively studied in experimental in vitro and in vivo carcinogenesis models. Results have consistently shown that the chemopreventive agents derived from this class of vegetables of the Cruciferae family influence carcinogenesis during… 

Vegetable Diet in Cancer Prevention

A negative correlation between consumption of vegetables and cancer risk is revealed and the mechanism of action of active components of vegetables, experimental studies, and clinical trials are described.

Cancer Chemoprevention by Natural Products: How Far Have We Come?

Novel technologies, such as nanotechnology, along with a better understanding of cancer stem cells, are certain to continue the advancement of the field of cancer chemoprevention in years to come.

Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach.

This review evaluates current knowledge on the mechanisms of CRC and LC prevention by vegetables, thereby focusing on the modulation of gene and protein expressions.

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

A number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells, and could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.

Cruciferous Vegetables and Their Bioactive Metabolites: from Prevention to Novel Therapies of Colorectal Cancer

The Brassicaceae family, known as cruciferous vegetables, includes many economically important species, mainly edible oil plants, vegetable species, spice plants, and feed plants. Cruciferous

Cruciferous vegetables consumption and lung cancer prevention: epidemiological studies and molecular mechanisms

Studies that show LC chemopreventive effects of cruciferous vegetables and their phytochemicals are reviewed, and the molecular mechanisms potentially involved in its prevention are described.

Dietary Carcinogens and Anticancer Effect of Bioactive Food Components

Awareness of the importance of consumption of functional foods or BFC as well asThe importance of the whole diet rather than the isolated compounds as a cancer-preventive strategy for the general public should be promoted.


The laboratory has extensively studied the interaction of two potentially anti-carcinogenic compounds in broccoli, the glucosinolate breakdown product, sulforaphane (St), and the essential mineral selenium (Se), and shown that enhancing broccoli with seenium results in reduction in the Sf content.



Perspectives in cancer chemoprevention.

The objective of this paper is to provide a general discussion of the mechanisms through which chemopreventive agents inhibit carcinogenesis, and examples of agents that act through these mechanisms are given.

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

An approach to chemoprevention of common forms of epithelial cancer, during the period of preneoplasia, is described and the potential future usefulness of this approach to cancer prevention in man will depend on further synthetic modification of the retinoid molecule.

Epidemiological studies on brassica vegetables and cancer risk.

It is concluded that a high consumption of brassica vegetables is associated with a decreased risk of cancer, and this association appears to be most consistent for lung, stomach, colon, and rectal cancer and least consistent for prostatic, endometrial, and ovarian cancer.

Antitumour promoting activity of indole-3-carbinol in mouse skin carcinogenesis.

Inhibition of Proliferation and Modulation of Estradiol Metabolism: Novel Mechanisms for Breast Cancer Prevention by the Phytochemical Indole-3-Carbinol

The preventive efficacy of 13C on human mammary carcinogenesis may be due in part to its ability to regulate cell-cycle progression, increase the formation of antiproliferative E2 metabolite, and induce cellular apoptosis.

Dietary constituents altering the responses to chemical carcinogens.

Since previous work has shown that synthetic inducers may protect against chemical carcinogens, the composition of the diet could play a role in inhibiting the neoplastic response to these carcinogenic agents.

Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol.

The results support previous studies that indole-3-carbinol can prevent mammary carcinogenesis by direct and indirect acting carcinogens and might be a good candidate for chemoprevention of breast cancer in women.

Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage.

Brassinin may be effective as a chemopreventive agent during both the initiation and promotion phases of carcinogenesis, and the synthetic route described herein has proven amenable for scale-up production.

Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.

  • S. Hecht
  • Chemistry, Biology
    The Journal of nutrition
  • 1999
On the basis of observations and knowledge of the carcinogenic constituents of cigarette smoke, a strategy for chemoprevention of lung cancer can be developed.