Cruciferous Vegetable Intake and Cancer Prevention: Role of Nutrigenetics

@article{Ambrosone2009CruciferousVI,
  title={Cruciferous Vegetable Intake and Cancer Prevention: Role of Nutrigenetics},
  author={Christine B. Ambrosone and Li Tang},
  journal={Cancer Prevention Research},
  year={2009},
  volume={2},
  pages={298 - 300}
}
Perspective on Navarro et al., [p. 345][1] The field of nutritional epidemiology has used an observational study approach in identifying food groups, foods, and specific nutrients that seem to be associated with reduced cancer risk. These findings led to a number of chemoprevention trials, 

Figures from this paper

Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables
TLDR
Current knowledge on mechanisms of action of erucin in chemoprevention obtained from cell and animal models are presented and it is related to other isothiocyanates.
The synergistic effect between the Mediterranean diet and GSTP1 or NAT2 SNPs decreases breast cancer risk in Greek-Cypriot women
TLDR
The homozygous null GSTT1 genotype could be a risk allele for BC among Greek-Cypriot women and the anticarcinogenic effects of the high adherence to MD against BC risk could also be further enhanced when combined with the wild-type alleles of the detoxification GSTP1 or NAT2 SNPs.
Sulforaphane: translational research from laboratory bench to clinic.
TLDR
This review considers whether an appropriately validated sulforaphane-yielding broccoli sprout supplement may deliver clinical benefit, and summarizes the findings of in vitro studies and clinical trials, interpreting them in the context of clinical relevance.
Cancer Chemoprevention by Natural Products: How Far Have We Come?
TLDR
Novel technologies, such as nanotechnology, along with a better understanding of cancer stem cells, are certain to continue the advancement of the field of cancer chemoprevention in years to come.
Cancer Prevention Research: Back to the Future
  • S. Lippman
  • Psychology
    Cancer Prevention Research
  • 2009
This issue of the journal marks the first anniversary of the print editions of Cancer Prevention Research ( CaPR ), which seems a good time to reflect on the remarkable history of the field that CaPR
Cancer Chemopreventive Effects of the Flavonoid-Rich Fraction Isolated from Papaya Seeds
TLDR
This is the first demonstration of chemopreventive activities of papaya seed products, and supports the inverse association between dietary flavonoid intake and cancer risk.
Cancer prevention: from 1727 to milestones of the past 100 years.
The rich, multidisciplinary history of cancer prevention recounted here begins with surgical and workplace recommendations of the 1700s and ends with 2009 results of the enormous (35,535 men)
Progress against cancer (1971–2011): how far have we come?
Tiwari AK, Roy HK (NorthShore University HealthSystem; Evanston, IL, USA). Progress against Cancer (1971–2011): how far have we come? (Historical Perspectives). J Intern Med 2012; 271: 392–399.
Mass Spectrometry Analysis of Nrf2-Keap1 Chemoprevention Signaling Pathway
TLDR
Mass spectrometry was employed to screen natural product extracts for possible chemopreventive agents that can activate ARE-mediated gene expression and facilitate clarification of the Nrf2-Keap1 signaling pathway mechanism in terms of cysteine alkylation, reversibility of the Cysteine-electrophile adducts and protein 3D structure.
Evaluation of Nutritional Compositions and Antioxidant Activity of Brassica oleracea (Cauliflower)
The present study intended to investigate the nutritional composition and antioxidant activity of cauliflower. Preliminary phytochemical tests were carried out by test tubes method indicating the
...
...

References

SHOWING 1-10 OF 29 REFERENCES
Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence
TLDR
The current epidemiological evidence suggests that cruciferous vegetable consumption may reduce the risk only of gastric and lung cancers, and there is at present no conclusive evidence that the consumption of crucifierous vegetables attenuates the risk of all other cancers.
Dual Association of beta-carotene with risk of tobacco-related cancers in a cohort of French women.
TLDR
Beta-carotene intake was inversely associated with risk of tobacco-related cancers among nonsmokers with a statistically significant dose-dependent relationship, whereas high beta-carotinine intake was directly associated withrisk among smokers.
Dietary isothiocyanates as confounding factors in the molecular epidemiology of colon cancer.
  • B. Ketterer
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1998
TLDR
Because Lin et a!. suggest that their findings are the consequence of reduced conjugation of sulforaphane among GSTM 1 null subjects, this commentary will attempt to assemble data available relating to this hypothesis to assess its validity.
Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial.
TLDR
Results based on the pre-specified analytic method are presented, details about risk factors for lung cancer, and analyses of subgroups and of factors that possibly influence response to the intervention are presented.
Cruciferous Vegetable Feeding Alters UGT1A1 Activity: Diet- and Genotype-Dependent Changes in Serum Bilirubin in a Controlled Feeding Trial
TLDR
Evaluation of the effects of diet stratified by GST genotype revealed some statistically significant genotypic differences; however, the magnitude was similar and not statistically significant between genotypes.
Cigarettes: a smoking gun in cancer chemoprevention.
TLDR
Although quite provocative, these results are subject to certain limitations and the totality of the evidence that tobacco smoking modifi es the chemopreventive is still unclear.
UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial.
TLDR
The results suggest that serum bilirubin glucuronidation is modulated by dietary intervention, but factors such as UGT1A1 genotype and sex may affect the response to diet.
Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance.
BACKGROUND Experimental and epidemiologic investigations suggest that alpha-tocopherol (the most prevalent chemical form of vitamin E found in vegetable oils, seeds, grains, nuts, and other foods)
Ornithine Decarboxylase G316A Genotype Is Prognostic for Colorectal Adenoma Recurrence and Predicts Efficacy of Aspirin Chemoprevention
TLDR
The ODC G316A genotype has the potential to be a clinically useful genetic marker to identify individuals likely to derive the greatest benefit from aspirin chemoprevention and is prognostic for CRA recurrence and predictive of an enhanced response to aspirin in preventing recurrence.
...
...