Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics.

@article{Mailloux2012CrucialYD,
  title={Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics.},
  author={Ryan J Mailloux and Cyril Nii-Klu Adjeitey and Jian Ying Xuan and M H Harper},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 1},
  pages={363-75}
}
Reduced glutathione (GSH) is the major determinant of redox balance in mitochondria and as such is fundamental in the control of cellular bioenergetics. GSH is also the most important nonprotein antioxidant molecule in cells. Surprisingly, the effect of redox environment has never been examined in skeletal muscle and brown adipose tissue (BAT), two tissues that have exceptional dynamic range and that are relevant to the development of obesity and related diseases. Here, we show that the redox… CONTINUE READING