Crucial roles of Brn1 in distal tubule formation and function in mouse kidney.

@article{Nakai2003CrucialRO,
  title={Crucial roles of Brn1 in distal tubule formation and function in mouse kidney.},
  author={Shigeyasu Nakai and Y. Sugitani and Hiroshi Sato and Sadayoshi Ito and Yukio Miura and Masaharu Ogawa and Miyuki Nishi and Kou-ichi Jishage and Osamu Minowa and Tetsuo Noda},
  journal={Development},
  year={2003},
  volume={130 19},
  pages={4751-9}
}
This study identifies a role for the gene for the POU transcription factor Brn1 in distal tubule formation and function in the mammalian kidney. Normal development of Henle's loop (HL), the distal convoluted tubule and the macula densa was severely retarded in Brn1-deficient mice. In particular, elongation and differentiation of the developing HL was affected. In the adult kidney, Brn1 was detected only in the thick ascending limb (TAL) of HL. In addition, the expression of a number of TAL… CONTINUE READING

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