Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling.

@article{Ma2009CrucialRO,
  title={Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling.},
  author={Hui Ma and Trevor B. Blake and Ajay Chitnis and Paul Liu and Tamas Balla},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 23},
  pages={4303-10}
}
Phosphatidylinositol 4-kinases (PI4Ks) catalyze the first committed step in the synthesis of phosphoinositides, important lipid regulators of signaling and trafficking pathways. Here we cloned Pik4a, one of the zebrafish PI4K enzymes, and studied its role(s) in vertebrate development using morpholino oligonucleotide-based gene silencing in zebrafish. Downregulation of Pik4a led to multiple developmental abnormalities, affecting the brain, heart, trunk and most prominently causing loss of… CONTINUE READING

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Characterization of a soluble adrenal phosphatidylinositol 4 - kinase reveals wortmannin - sensitivity of Type III phosphatidylinositol 4 - kinases

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