Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

@article{Chen2005CrucialRO,
  title={Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis},
  author={Zhenbang Chen and Lloyd C Trotman and David Shaffer and Hui-Kuan Lin and Zohar A. Dotan and Masaru Niki and Jason A Koutcher and Howard I. Scher and Thomas Ludwig and William Gerald and Carlos Cordon-Cardo and Pier Paolo Pandolfi},
  journal={Nature},
  year={2005},
  volume={436},
  pages={725-730}
}
Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance of senescence in vivo has not been established. The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in human cancer including prostate cancer. Although they are functionally distinct, reciprocal cooperation has been proposed, as PTEN is thought to regulate p53 stability, and p53 to enhance PTEN transcription… CONTINUE READING
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