Crucial role of nonspecific interactions in amyloid nucleation

  title={Crucial role of nonspecific interactions in amyloid nucleation},
  author={Anđela {\vS}ari{\'c} and Yassmine Chebaro and Tuomas P. J. Knowles and Daan Frenkel},
  journal={Proceedings of the National Academy of Sciences},
  pages={17869 - 17874}
Significance The assembly of normally soluble proteins into large fibrils, known as amyloid aggregation, is associated with a range of pathologies. Prefibrillar protein oligomers but not the grown fibers are believed to be the main toxic agents. It is unresolved if these oligomers are necessary for fibril assembly or just a dangerous byproduct. We show using computer simulations that, at physiological concentrations, amyloid formation must proceed through a two-step process including… 

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