Crucial role of interleukin-4 in the survival of colon cancer stem cells.

  title={Crucial role of interleukin-4 in the survival of colon cancer stem cells.},
  author={Maria Giovanna Francipane and Mileidys Perez Alea and Ylenia Lombardo and Matilde Todaro and Jan Paul Medema and Giorgio Stassi},
  journal={Cancer research},
  volume={68 11},
Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance to clinical cytotoxic therapies and recent work suggests that this resistance may be mediated in part by an autocrine response to the immune cytokine interleukin 4 (IL-4). Blocking IL-4 signaling can sensitize CSCs to apoptotic stimuli and increase the in vivo efficacy of cytotoxic therapy. These findings suggest… CONTINUE READING

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