Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

@article{Matsuzaka2007CrucialRO,
  title={Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance},
  author={Takashi Matsuzaka and Hitoshi Shimano and Naoya Yahagi and Toyonori Kato and Ayaka Atsumi and Takashi Yamamoto and Noriyuki Inoue and Mayumi Ishikawa and Sumiyo Okada and Naomi Ishigaki and Hitoshi Iwasaki and Yuko Iwasaki and Tadayoshi Karasawa and Shin Kumadaki and Toshiyuki Matsui and Motohiro Sekiya and Ken Ohashi and Alyssa H Hasty and Yoshimi Nakagawa and Akimitsu Takahashi and Hiroaki Suzuki and Sigeru Yatoh and Hirohito Sone and Hideo Toyoshima and Jun-ichi Osuga and Nobuhiro Yamada},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={1193-1202}
}
Insulin resistance is often associated with obesity and can precipitate type 2 diabetes. To date, most known approaches that improve insulin resistance must be preceded by the amelioration of obesity and hepatosteatosis. Here, we show that this provision is not mandatory; insulin resistance and hyperglycemia are improved by the modification of hepatic fatty acid composition, even in the presence of persistent obesity and hepatosteatosis. Mice deficient for Elovl6, the gene encoding the elongase… CONTINUE READING
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