Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells.

@article{Santourlidis2002CrucialRO,
  title={Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells.},
  author={Simeon Santourlidis and Hans-Ingo Trompeter and Sandra Weinhold and Britta Eisermann and Klaus L. Meyer and Peter Wernet and Markus Uhrberg},
  journal={Journal of immunology},
  year={2002},
  volume={169 8},
  pages={4253-61}
}
Human NK cells are characterized by the expression of surface receptors of the killer cell Ig-like receptor (KIR) family, which are involved in the specific recognition of pathogenic target cells. Each NK cell expresses and maintains an individual subset of inhibitory and stimulatory KIR and in this way contributes to a diversified NK cell repertoire. To date, the molecular basis for generation of clonally distributed KIR expression patterns has been elusive. Here, analyses of DNA methylation… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

Similar Papers

Loading similar papers…