Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions.

@article{Song2012CrucialRO,
  title={Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions.},
  author={Zifang Song and Rong De Jin and Shiyong Yu and A Irjinia Putri Nanda and Daniel Neil Granger and Guohong Li},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 1},
  pages={
          50-64
        }
}
OBJECTIVE It has been shown that CD40-TRAF6 axis in leukocytes plays a significant role in neointimal formation after carotid ligation. Because CD40 and TRAF6 are expressed not only in leukocytes but also in vascular cells, we examined the role of CD40 contributed by vascular wall cells in neointimal formation after carotid ligation in an atherogenic environment. METHODS AND RESULTS Both CD40 and TRAF6 in medial smooth muscle cells (SMCs) was upregulated significantly at 3 days and more… CONTINUE READING
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