Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain.

@article{Rcz2008CrucialRO,
  title={Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain.},
  author={Ildik{\'o} R{\'a}cz and Xavier Nadal and Judith Alferink and Josep Eladi Ba{\~n}os and Jennifer Rehnelt and Miquel Martin and Bel{\'e}n Pintado and Alfonso Guti{\'e}rrez-Ad{\'a}n and Elena Sanguino and Jorge Manzanares and Andreas Zimmer and Rafael Gonz{\'a}lez Maldonado},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 46},
  pages={
          12125-35
        }
}
Neuropathic pain is a clinical manifestation of nerve injury difficult to treat even with potent analgesic compounds. Here, we used different lines of genetically modified mice to clarify the role played by CB(2) cannabinoid receptors in the regulation of the central immune responses leading to the development of neuropathic pain. CB(2) knock-out mice and wild-type littermates were exposed to sciatic nerve injury, and both genotypes developed a similar hyperalgesia and allodynia in the… CONTINUE READING

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