Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity.

@article{Fruttiger1995CrucialRF,
  title={Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity.},
  author={Marcus Fruttiger and Dirk Montag and Melitta Schachner and Rudolf Martini},
  journal={The European journal of neuroscience},
  year={1995},
  volume={7 3},
  pages={511-5}
}
It has recently been shown that mice deficient in the gene for myelin-associated glycoprotein develop normal myelin sheaths in the peripheral nervous system. Here we report that in mutant mice older than 8 months the maintenance of axon-myelin units is disturbed, resulting in both axon and myelin degeneration. Morphological features include those typically seen in human peripheral neuropathies, where demyelination-induced Schwann cell proliferation and remyelination lead to the formation of so… CONTINUE READING
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