Crucial importance of PKC-β(I) in LFA-1–mediated locomotion of activated T cells

  title={Crucial importance of PKC-β(I) in LFA-1–mediated locomotion of activated T cells},
  author={Yuri Volkov and Aideen Long and Sara McGrath and D{\'e}irdre N{\'i} Eidhin and Dermot Kelleher},
  journal={Nature Immunology},
Crawling T cell locomotion in which activated lymphocyte function–associated antigen 1 (LFA-1) integrins participate is associated with translocation of the protein kinase C-β (PKC-β) isoenzyme to the microtubule cytoskeleton. In normal T cells and T lymphoma cell lines, this type of motility is accompanied by PKC-β–sensitive cytoskeletal rearrangements and the formation of trailing cell extensions, which are supported by microtubules. Expression of PKC-β(I) and enhanced green fluorescent… CONTINUE READING
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