Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

@article{Katagiri2004CrucialFO,
  title={Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking},
  author={Koko Katagiri and Noriko Ohnishi and Kenji Kabashima and Tomonori Iyoda and Naoki Takeda and Yoichi Shinkai and Kayo Inaba and Tatsuo Kinashi},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={1045-1051}
}
Immunosurveillance requires the coordinated regulation of chemokines and adhesion molecules to guide immune cell migration. However, the critical molecule for governing the high trafficking capability of immune cells is not clear. Here we show that the effector molecule RAPL is indispensable in the integrin-mediated adhesion and migration of lymphocytes and dendritic cells. RAPL deficiency caused defective chemokine-triggered lymphocyte adhesion and migration to secondary lymphoid organs… Expand
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