Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

@article{Katagiri2004CrucialFO,
  title={Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking},
  author={K. Katagiri and N. Ohnishi and K. Kabashima and T. Iyoda and N. Takeda and Y. Shinkai and K. Inaba and T. Kinashi},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={1045-1051}
}
Immunosurveillance requires the coordinated regulation of chemokines and adhesion molecules to guide immune cell migration. However, the critical molecule for governing the high trafficking capability of immune cells is not clear. Here we show that the effector molecule RAPL is indispensable in the integrin-mediated adhesion and migration of lymphocytes and dendritic cells. RAPL deficiency caused defective chemokine-triggered lymphocyte adhesion and migration to secondary lymphoid organs… Expand
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Rap1 and integrin inside-out signaling.
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