Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases.

@article{Rostan2015CrucialAD,
  title={Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases.},
  author={Octavie Rostan and Muhammad Imran Arshad and Claire Piquet-Pellorce and Florence Robert-Gangneux and J. P. Gangneux and Michel Samson},
  journal={Infection and immunity},
  year={2015},
  volume={83 5},
  pages={1738-48}
}
Interleukin-33 (IL-33) has now emerged as a cytokine with diverse and pleiotropic functions in various infectious and inflammatory diseases. IL-33 is expressed by epithelial cells, endothelial cells, fibroblasts, and hepatocytes. The target cells of IL-33 are Th2 cells, basophils, dendritic cells, mast cells, macrophages, NKT cells, and nuocytes, newly discovered natural helper cells/innate lymphoid cells bearing the ST2 receptor. IL-33 has dual functions, both as a traditional cytokine and as… CONTINUE READING