Crucial Involvement of Tumor-Associated Neutrophils in the Regulation of Chronic Colitis-Associated Carcinogenesis in Mice

@inproceedings{Shang2012CrucialIO,
  title={Crucial Involvement of Tumor-Associated Neutrophils in the Regulation of Chronic Colitis-Associated Carcinogenesis in Mice},
  author={Kun Shang and Yu-Pan Bai and Chen Wang and Zhen Wang and Hong-Yu Gu and Xiang Du and Xiaoyan Zhou and Chun-Lei Zheng and Ya-yun Chi and Naofumi Mukaida and Yingyi Li},
  booktitle={PloS one},
  year={2012}
}
Ulcerative colitis (UC) is a major form of chronic inflammation that can frequently progress to colon cancer. Several studies have demonstrated massive infiltration of neutrophils and macrophages into the lamina propria and submucosa in the progression of UC-associated colon carcinogenesis. Macrophages contribute to the development of colitis-associated colon cancer (CAC). However, the role of neutrophils is not well understood. To better understand the involvement of tumor-associated… CONTINUE READING
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