Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease


Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.

DOI: 10.1016/j.jalz.2016.02.006

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@article{Allen2016CrowdsourcedEO, title={Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease}, author={Genevera I. Allen and Nicola Amoroso and Catalina Anghel and Venkat S. K. Balagurusamy and Christopher J. Bare and Derek Beaton and Roberto Bellotti and David A. Bennett and Kevin L. Boehme and Paul C. Boutros and Laura Caberlotto and Cristian Caloian and Frederick C Campbell and Elias Chaibub Neto and Yu-Chuan Chang and Beibei Chen and Chien-Yu Chen and Ting-Ying Chien and Tim Clark and Sudeshna Das and Christos Davatzikos and Jieyao Deng and Donna Dillenberger and Richard J. B. Dobson and Qilin Dong and Jimit Doshi and Denise Duma and Rosangela Errico and G Erus and Evan Everett and David W. Fardo and Stephen H. Friend and Holger Fr{\"{o}hlich and Jessica Gan and Peter H. St George-Hyslop and Satrajit S. Ghosh and Enrico Glaab and Robert C. Green and Yuanfang Guan and Ming-Yi Hong and Chao Huang and Jinseub Hwang and Joseph G. Ibrahim and Paolo Inglese and Anandhi Iyappan and Qijia Jiang and Yuriko Katsumata and John S. K. Kauwe and Arno Klein and Dehan Kong and Roland Krause and Emilie Lalonde and Mario Lauria and Eunjee Lee and Xihui Lin and Zhandong Liu and Julie Livingstone and Benjamin A. Logsdon and Simon Lovestone and Tsung-wei Ma and Ashutosh Malhotra and Lara M Mangravite and Taylor J. Maxwell and Emily Merrill and John Nagorski and Aishwarya Namasivayam and Manjari Narayan and Mufassra Naz and Stephen Newhouse and Thea Norman and Ramil N. Nurtdinov and Yen-Jen Oyang and Yudi Pawitan and Shengwen Peng and Mette A. Peters and Stephen R. Piccolo and Paurush Praveen and Corrado Priami and Veronica Y. Sabelnykova and Philipp Senger and Xia Shen and Andrew Simmons and Aristeidis Sotiras and Gustavo Stolovitzky and Sabina Sonia Tangaro and Andrea Tateo and Yi-An Tung and Nicholas J. Tustison and Erdem Varol and George Vradenburg and Michael W Weiner and Guanghua Xiao and Lei Xie and Yang Xie and Jia Xu and Hojin Yang and Xiaowei Zhan and Yunyun Zhou and Fan Zhu and Hongtu Zhu and Shanfeng Zhu}, journal={Alzheimer's & Dementia}, year={2016}, volume={12}, pages={645-653} }