Crowding-induced structural alterations of random-loop chromosome model.

  title={Crowding-induced structural alterations of random-loop chromosome model.},
  author={Jun Soo Kim and Vadim Backman and Igal Szleifer},
  journal={Physical review letters},
  volume={106 16},
We investigate structural alterations of random-loop polymers due to changes in the crowding condition, as a model to study environmental effects on the structure of chromosome subcompartments. The polymer structure is changed in a nonmonotonic fashion with an increasing density of crowders: condensed at small volume fractions; decondensed at high crowding volume fractions. The nonmonotonic behavior is a manifestation of the nontrivial distance dependence of the depletion interactions. We also… CONTINUE READING

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